Santee Inn

Exterior of a Best Western Plus hotel during twilight with a lit sign, palm trees, and a brick building with arched windows and a porch.

Tucked beneath the swaying pines of South Carolina’s low country, just off the winding ease of I-95, you’ll find a haven of rest, relaxation, and Southern hospitality. Whether you're here to chase birdies across championship greens or simply seeking a peaceful stop on your journey, the Best Western Plus Santee Inn offers the perfect blend of comfort and convenience.

Our guests return year after year, drawn by the warmth of our staff, and the promise of a stay that feels like home—but better. From a refreshing dip in our outdoor pool to a hearty hot breakfast served with a smile, every detail is designed to make your stay seamless and memorable.

Located minutes from Lake Marion and surrounded by some of the most celebrated golf courses in the region, we’re more than a place to rest—we’re a destination. Whether you're teeing off with old friends, gathering for a group getaway, or traveling through with family, we welcome you with open doors and open hearts.

Come discover why guests call us their favorite stop in South Carolina. The greens are waiting, the beds are made, and your keys are at the desk.

Hotel room with a bed, two orange chairs, a small side table, and colorful paintings of sailboats on the wall.

King Rooms

Spacious and serene, our King Rooms offer the perfect retreat for solo travelers or couples seeking restful comfort. Each room features one plush king-sized bed, soft lighting, and classic furnishings to make you feel right at home.

A hotel room with three beds, wooden headboards, white bedding, nightstands with lamps, a window with curtains, and wooden furniture.

Queen Rooms

Ideal for families or guests traveling together, our Queen Rooms include two comfortable queen-sized beds and ample space to unwind after a day on the road—or the fairway. An ADA-accessible Queen Room is also available upon request, offering thoughtful features to ensure a comfortable and convenient stay for all travelers.

Amenities Designed for Comfort & Convenience

At Best Western Plus Santee Inn, every detail is designed to make your stay as easy and enjoyable as possible. Whether you’re starting your day with a hot breakfast or winding down with a swim beneath the stars, you’ll find comfort and convenience around every corner.

A large building with a porch and columns, surrounded by green grass and bushes, with a brick walkway leading to the entrance, under a partly cloudy blue sky.
Outdoor public swimming pool with sun loungers, pavilion, and clear blue sky.

Guests love the convenience of Captain’s Quarters, located just next door. Whether you're craving a hearty steak, fresh seafood, or Southern classics, you won’t have to go far for a great meal.

Cool off after a long day on the road or the green with a refreshing dip in our outdoor pool. Surrounded by peaceful trees and sunshine, it’s the perfect spot to relax and recharge.

A breakfast plate with scrambled eggs and two slices of cooked bacon, served on a white plate on a beige napkin. A cup of black coffee is in a white mug, and a bowl of biscuits with gravy is nearby on a wooden table.

Fuel your day with a satisfying Southern spread, served fresh every morning. Enjoy hot biscuits and gravy, grits, pastries, fruit, cereal, juice, coffee, and more—all complimentary with your stay.

Various snacks, drinks, and souvenirs displayed on a wooden surface with a promotional message about the sundry shop's availability.

Forgot your toothbrush? Need a quick snack or souvenir? Visit our convenient on-site sundry shop for travel essentials, cold drinks, and locally inspired goodies.

Golf Getaways Made Easy
Whether you're here for a quick round or a full week on the greens, we’ve partnered with Santee’s best courses to bring you exclusive stay-and-play deals.
Enjoy comfortable lodging, daily breakfast, and tee times at top-rated golf clubs—all just minutes from your room.

Golf Packages